Characterisation of a reconfigurable free space optical interconnect system for parallel computing applications and experimental validation using rapid prototyping technology

Free-space optical interconnects (FSOIs) are widely seen as a potential solution to present and future bandwidth bottlenecks for parallel processing applications. This thesis will be focused on the study of a particular FSOI system called Optical Highway (OH). The OH is a polarised beam routing system which uses Polarising Beam Splitters and Liquid Crystals (PBS/LC) assemblies to perform reconfigurable interconnection networks. The properties of the OH make it suitable for implementing different passive static networks. A technology known as Rapid Prototyping (RP) will be employed for the first time in order to create optomechanical structures at low cost and low production times. Off-theshelf optical components will also be characterised in order to implement the OH. Additionally, properties such as reconfigurability, scalability, tolerance to misalignment and polarisation losses will be analysed. The OH will be modelled at three levels: node, optical stage and architecture. Different designs will be proposed and a particular architecture, Optimised Cut-Through Ring (OCTR), will be experimentally implemented. Finally, based on this architecture, a new set of properties will be defined in order to optimise the efficiency of the optical channels

Active implants in the middle ear pathology

[ES] Los implantes activos son útiles en el tratamiento de la hipoacusia neurosensorial, mixta con umbrales óseos superiores a 45 dB y algunas sorderas de transmisión. Constituyen una herramienta eficaz en pacientes que cumplen los criterios audiológicos y biológicos de cada uno de los sistemas. Proporcionan mejoras tonales y en la discriminación verbal similares a las audioprótesis externas, con mejor calidad del sonido. [EN] The active implants are useful in the treatment of sensorineural hearing loss, mixed deafness with bone thresholds above 45 dB and some transmission deafness. They are an effective tool for patients who meet the audiological and biological criteria. Provides tonal improvements and similar verbal discrimination external hearing aids with better sound quality

Extramedullary plasmocytoma in base of tongue

[ES] Introducción: El plasmocitoma extramedular es un tumor de células plasmáticas monoclonales que ocurre fuera de la médula o del hueso.La localización mas frecuente en otorrinolaringología asienta en las fosas nasales y senos paranasales, presentándose en el 80% de los casos como una masa solitaria de tejido blando. Paciente/método: Varón de 80 años con cardiopatía isquémica, insuficiencia renal crónica e hipertensión. Acude a urgencias por espina de pescado, localizada en hemibase de lengua derecha y extraída. Se aprecia en línea media tumoración rojiza de 2 cm. La nasofibroscopia muestra tumoración limitada a base de lengua, no ulcerada.La RMN revela una tumoración en base de lengua de 2,5cm con intensa captación de gadolineo. Se establece diagnóstico diferencial con tiroides lingual y rabdomioma, descartándose patología tiroidea tras gammagrafía. El paciente, informado de la necesidad de biopsia/exéresis, rechaza actitud quirúrgica y seguimiento. Tras 1 año y 2 meses, ingresa en Medicina interna por dolores óseos erráticos. En pruebas radiológicas se objetivan múltiples lesiones óseas junto a lesión nodular en axila derecha con PAAF compatible con proceso linfoproliferativo. Biopsia de médula ósea sin evidencia de infiltración neoplásica. Se realiza adenectomía axilar derecha con diagnóstico anatomopatológico de plasmocitoma extramedular. Resultado: La enfermedad local evolucionó a mieloma múltiple sin infiltración medular. Se establece quimioterapia con protocolo VMP. Tras 2 ciclos, el paciente decide la suspensión. Discusión/Conclusión: El plasmocitoma extramedular faríngeo es poco frecuente manifestándose en el 5% de los casos. La toma de biopsia es fundamental para el diagnóstico debiendo realizarse tomas profundas ya que el plasmocitoma asienta en la submucosa. [EN] Introduction: Extramedullary plasmocytoma is a plasma cell neoplasia that arises outside of the bone marrow or bone.The most frequent locations in the otorrinolaryngologist area are nostrils and nasal sinuses. In 80% of the cases solitary plasmocytoma appears like a soft tissue mass. Patient and methods: Case report: An 80-years old male, with ischaemic heart disease, chronic renal failure and hypertension came to the emergency service complaining of fishbone, located in right base of tongue and removed after exploration. A reddish 2 cm mass is observed in the midline.Endoscopy showed up a mass limited to base of tongue, non ulcerated. The MRI revealed a mass in base of the tongue with 2, 5 cm and intense uptake of gadolinium was discovered. Differential diagnosis is established between lingual thyroid and rhabdomyoma.Thyroid pathology is dismissed after thyroid scan. The patient is informed of the need of biopsy/excision and rejects surgery and monitoring. After 1 year and 2 months the patient is admited to Internal medicine, complaining of erratic bone pains. Imaging studies showed multiples bones lesions, also one nodular lesion in the right axila is found with FNAC compatible with lymphoproliferative process. Bone marrow biopsy did not show evidence of neoplasic infiltration. An axilar right adenectomy is performed with pathologist diagnosis of extramedularry plasmocytoma. Results: Local disease evolved to multiple myeloma without bone marrow infiltration. Chemotherapy with VMP protocol is established, after 2 cycles , the patient decide to interrupt treatment. Conclusions: Pharingeal extramedularry plasmocytoma is infrequent manifesting itself in 5% of cases. Taking a biopsy in deep is essential for diagnosis, as plasmacytoma sits in the submucosa

Specialized proresolving mediators protect against experimental autoimmune myocarditis by modulating Ca2+ handling and NRF2 activation

Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, which prevents sarcoplasmic reticulum–adenosine triphosphatase 2A down-regulation and Ca2+ mishandling, and attenuates the cardiac dysfunction and tissue damage induced by myocarditis.This work was supported by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund (SAF-2017-84777R), Instituto de Salud Carlos III (ISCIII) (PI17/01093, PI17/01344, and PI20/01482), Sociedad Española de Cardiología, Proyecto Traslacional 2019 and Asociación del Ritmo Cardiaco (SEC, España), Proyecto Asociación Insuficiencia Cardiaca (Trasplante Cardiaco) 2020, Fondo Europeo de Desarrollo Regional, Fondo Social Europeo, and CIBERCV, a network funded by ISCIII, Spanish Ministry of Science, Innovation and Universities (PGC2018-097019-B-I00), Ministerio de Economía, Industria y Competitividad/Agencia Estatal de Investigación 10.13039/501100011033 PID2020-113238RB-I00, PID2019-105600RB-I00, the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria grant PRB3 [PT17/0019/0003-ISCIII-SGEFI/ERDF, ProteoRed]), and “la Caixa” Foundation (project code HR17-00247). The Centro Nacional de Investigaciones Cardiovasculares is supported by the ISCIII, the Ministerio de Ciencia, Innovación y Universidades. Dr Ruiz-Hurtado is Miguel Servet I researcher of ISCIII (CP15/00129 Carlos III Health Institute). Dr Tamayo and R.I. Jaén, and M. Gil-Fernández were or currently are PhD students funded by the Formación de Profesorado Universitario program of the Spanish Ministry of Science, Innovation and Universities (FPU17/06135; FPU16/00827, FPU1901973)

Specialized proresolving mediators protect against experimental autoimmune myocarditis by modulating Ca2+ handling and NRF2 activation

Preclinical research[Abstract] Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, which prevents sarcoplasmic reticulum–adenosine triphosphatase 2A down-regulation and Ca2+ mishandling, and attenuates the cardiac dysfunction and tissue damage induced by myocarditis.Ministerio de Economía y Competitividad (España); SAF-2017-84777RInstituto de Salud Carlos III; PI17/01093Instituto de Salud Carlos III; PI17/01344Instituto de Salud Carlos III; PI20/01482Ministerio de Ciencia, Innovación y Universidades (España); PGC2018-097019-B-I00Ministerio de Economía, Industria y Competitividad (España); 10.13039/501100011033Ministerio de Industria, Economía y Competitividad; PID2020-113238RB-I00Ministerio de Industria, Economía y Competitividad (España); PID2019-105600RB-I00Fundación La Caixa; HR17-0024

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

El Derecho del Trabajo y de la Seguridad Social en España en 2016. Sección Juvenil de la Asociación Española de Derecho del Trabajo y de la Seguridad Social

En su quinta edición, el Informe “El Derecho del Trabajo y de la Seguridad Social en España 2018” le ofrece una síntesis, que por concreta no es menos rigurosa, de los principales hitos por los que ha transitado el iuslaboralismo a lo largo del último año. En concreto, en las páginas que siguen, los expertos integrantes de la Sección Juvenil de la Asociación Española de Derecho del Trabajo y de la Seguridad Social (AEDTSS) analizan para usted, en primer lugar, las principales resoluciones europeas y nacionales en materia de igualad y no discriminación, acoso en sus más diversas manifestaciones, liberad religiosa y libertad de expresión. Asimismo, se abordan también las cuestiones relativas al empleo y la contratación, casi monopolizadas por el impacto de las plataformas y las consecuencias del caso de Diego. En materia de vicisitudes, sin perder importancia el despido colectivo, observará un cierto auge de los casos relativos a sucesión empresarial, movilidad funcional y empleo público. En el ámbito del derecho colectivo, además de analizarse el IV AENC, encontrará un estudio pormenorizado de las principales resoluciones en materia de libertad sindical, representación unitaria y ultraactividad. La sección relativa a conciliación y corresponsabilidad incluye este año como novedad un apartado relativo a violencia de género, al hilo de los avances normativos derivados del Real Decreto-ley 9/2018. Los epígrafes concernientes a la protección social y la prevención de riesgos laborales crecen de forma significativa en esta edición, lo que ha permitido abordar la evolución jurisprudencial para buena parte de las prestaciones y riesgos previstos en la Ley. Por último, las expertas del apartado de derecho procesal se han encargado de revisar a fondo los casos más significativos en el marco de las modalidades procesales especiales, con especial hincapié en el ámbito concursal. También han abordado la jurisprudencia constitucional más reciente sobre el de recurso de reposición. En suma, tienen ante usted un trabajo científico consolidado en el tiempo y sólido en cuanto al contenido, fiel reflejo de, a pesar del difícil contexto, el buen hacer de la joven doctrina iuslaboralista española. The fifth edition of the report, "Labour and Social Security Law in Spain in 2018" analyses the key issues in the changing scenario of Labour Law and Social Security during last year. Elaborated by the Young Scholars’ Section of the Spanish Association of Labour and Social Security Law focuses on the following thematic blocks: non-specific fundamental rights; employment contracts and employment; issues related to employment relationship; collective rights; equality and co-responsibility; occupational risks prevention; and procedural law. In conclusion, you may find here a concrete but detailed analysis of the the main legal and case law novelties of Spanish Social Law

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Characterisation of a reconfigurable free space optical interconnect system for parallel computing applications and experimental validation using rapid prototyping technology

Free-space optical interconnects (FSOIs) are widely seen as a potential solution to present and future bandwidth bottlenecks for parallel processing applications. This thesis will be focused on the study of a particular FSOI system called Optical Highway (OH). The OH is a polarised beam routing system which uses Polarising Beam Splitters and Liquid Crystals (PBS/LC) assemblies to perform reconfigurable interconnection networks. The properties of the OH make it suitable for implementing different passive static networks. A technology known as Rapid Prototyping (RP) will be employed for the first time in order to create optomechanical structures at low cost and low production times. Off-theshelf optical components will also be characterised in order to implement the OH. Additionally, properties such as reconfigurability, scalability, tolerance to misalignment and polarisation losses will be analysed. The OH will be modelled at three levels: node, optical stage and architecture. Different designs will be proposed and a particular architecture, Optimised Cut-Through Ring (OCTR), will be experimentally implemented. Finally, based on this architecture, a new set of properties will be defined in order to optimise the efficiency of the optical channels.EThOS - Electronic Theses Online ServiceGBUnited Kingdo